At 2:48, that's Kate Mulgrew: the original notion of "Kate Loves a Mystery" was that she was Columbo's wife, but they eventually ditched that angle.
At 1:37, that's Bruce Jenner. If you weren't around in the 1970s, if you know Bruce Jenner for anything, it's as the stepdad of Kim Kardashian; what you didn't know was that he was a gold medalist in the 1976 Olympics, and took to advertising about 78% of all products sold in the US. In that one Patton Oswalt / Brian Posehn bit they refer to him as the "Wheaties faggot" because he was all over Wheaties boxes back in the day. Even John Belushi once parodied Jenner's Wheaties commercial on SNL.