Since you fine chaps have the opening covered, I guess I'll take the opportunity to recognize the closing credits instead.
That's a nice song. It's also like the only song in the entire soundtrack that's mostly in Japanese. And it's clever of them to use the sequence as a vehicle to reveal bits and pieces of Spike's backstory that didn't make it into the show proper.
Yoko Kanno (the composer) is a friggin' genius. Also, Ed is based directly on her.
Ed isn't Hispanic, she's just a weird little orange kid. Fun fact, though: apparently her father's name (Appledelhi Siniz Hesap Lütfen) is Turkish for "excuse me, check please."