Ehh, I don't think they're particularly uncomfortable at all (I used to stick them on my arms for fun when I was in grade school), although cats' sense of touch is a lot more sensitive than ours is.
Two days before someone deactivates a cat and leaves it in the middle of an interstate and watches it get run over. One week until leaving deactivated cats around in random places for people to find becomes an Internet sensation. One month before someone deactivates a cat and leaves it in the middle of an interstate and records it getting run over. It will be the most disliked video on the Internet.
"But what if we block the nerve impulse by simply applying local pressure which can be done with any ordinary metal clamp just at the swelling on the posterior nerve roots... for oh say... 5 or 6 seconds.
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WHY YOU MOTHER GRABBING BASTARD!